Raman spectroscopy for cell culture process monitoring 

It can also be used to implement nutrient control and specific feeding regimens for cell culture processes. A model development strategy was based on utilizing spectroscopic datasets collected with wide process variations, spiking, the use of chemometric algorithms to determine spectral regions of interest, and testing the feasibility of global and local calibrations. From a quality standpoint, higher galactosylation of the mAb was observed with lactic acid control.